兔抗KDM2A多克隆抗体

Background:

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least six highly degenerated leucine-rich repeats. This family member plays a role in epigenetic silencing. It nucleates at CpG islands and specifically demethylates both mono- and di-methylated lysine-36 of histone H3. Alternative splicing results in multiple transcript variants.

Applications:

ELISA, IHC

Name of antibody:

KDM2A

Immunogen:

Synthetic peptide of human KDM2A

Full name:

lysine demethylase 2A

Synonyms:

FBL7; CXXC8; FBL11; FBXL11; JHDM1A; LILINA

SwissProt:

Q9Y2K7

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human lung cancer and Human esophagus cancer

IHC Recommend dilution:

50-300