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Background: |
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region. |
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Applications: |
WB, IHC |
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Name of antibody: |
TFAP2A |
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Immunogen: |
Synthesized peptide derived from human AP-2. |
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Full name: |
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) |
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Synonyms： |
AP-2; BOFS; AP2TF; TFAP2; AP-2alpha |
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SwissProt: |
P05549 |
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IHC positive control: |
Human breast carcinoma tissue |
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IHC Recommend dilution: |
50-100 |
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WB Predicted band size: |
48 kDa |
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WB Positive control: |
COLO205 cells lysate |
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WB Recommended dilution: |
500-3000 |
