兔抗CYP21A2多克隆抗体

Background:

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates steroids at the 21 position. Its activity is required for the synthesis of steroid hormones including cortisol and aldosterone. Mutations in this gene cause congenital adrenal hyperplasia. A related pseudogene is located near this gene; gene conversion events involving the functional gene and the pseudogene are thought to account for many cases of steroid 21-hydroxylase deficiency. Two transcript variants encoding different isoforms have been found for this gene.

Applications:

ELISA, IHC

Name of antibody:

CYP21A2

Immunogen:

Fusion protein of human CYP21A2

Full name:

cytochrome P450, family 21, subfamily A, polypeptide 2

Synonyms:

CAH1; CPS1; CA21H; CYP21; CYP21B; P450c21B

SwissProt:

P08686

IHC positive control:

Human gastric cancer and human thyroid cancer

IHC Recommend dilution:

100-300