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别 名： inositol 1,4,5-trisphosphate receptor type 2; ANHD; IP3R2; CFAP48; INSP3R2
技术规格
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Background: |
The protein encoded by this gene belongs to the inositol 1,4,5-triphosphate receptor family, whose members are second messenger intracellular calcium release channels. These proteins mediate a rise in cytoplasmic calcium in response to receptor activated production of inositol triphosphate. Inositol triphosphate receptor-mediated signaling is involved in many processes including cell migration, cell division, smooth muscle contraction, and neuronal signaling. This protein is a type 2 receptor that consists of a cytoplasmic amino-terminus that binds inositol triphosphate, six membrane-spanning helices that contribute to the ion pore, and a short cytoplasmic carboxy-terminus. A mutation in this gene has been associated with anhidrosis, suggesting that intracellular calcium release mediated by this protein is required for eccrine sweat production. |
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Applications: |
ELISA, IHC |
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Name of antibody: |
ITPR2 |
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Immunogen: |
Synthetic peptide of human ITPR2 |
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Full name: |
inositol 1,4,5-trisphosphate receptor type 2 |
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Synonyms: |
ANHD; IP3R2; CFAP48; INSP3R2 |
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SwissProt: |
Q14571 |
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ELISA Recommended dilution: |
5000-10000 |
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IHC positive control: |
Human tonsil and Human esophagus cancer |
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IHC Recommend dilution: |
50-300 |
