兔抗ITPR2多克隆抗体

Background:

The protein encoded by this gene belongs to the inositol 1,4,5-triphosphate receptor family, whose members are second messenger intracellular calcium release channels. These proteins mediate a rise in cytoplasmic calcium in response to receptor activated production of inositol triphosphate. Inositol triphosphate receptor-mediated signaling is involved in many processes including cell migration, cell division, smooth muscle contraction, and neuronal signaling. This protein is a type 2 receptor that consists of a cytoplasmic amino-terminus that binds inositol triphosphate, six membrane-spanning helices that contribute to the ion pore, and a short cytoplasmic carboxy-terminus. A mutation in this gene has been associated with anhidrosis, suggesting that intracellular calcium release mediated by this protein is required for eccrine sweat production.

Applications:

ELISA, IHC

Name of antibody:

ITPR2

Immunogen:

Synthetic peptide of human ITPR2

Full name:

inositol 1,4,5-trisphosphate receptor type 2

Synonyms:

ANHD; IP3R2; CFAP48; INSP3R2

SwissProt:

Q14571

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human tonsil and Human esophagus cancer

IHC Recommend dilution:

50-300