兔抗ITGAL多克隆抗体

Background:

ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene.

Applications:

ELISA, IHC

Name of antibody:

ITGAL

Immunogen:

Synthetic peptide of human ITGAL

Full name:

integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)

Synonyms：

CD11A, LFA-1, LFA1A

SwissProt:

P20701

ELISA Recommended dilution:

1000-2000

IHC positive control:

Human esophagus cancer and Human liver cancer

IHC Recommend dilution:

15-50