小鼠抗RUNX1T1单克隆抗体

Background:

This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq].

Applications:

WB, IF

Name of antibody:

RUNX1T1

Immunogen:

Fusion protein of human RUNX1T1

Full name:

runt-related transcription factor 1; translocated to, 1 (cyclin D-related) (RUNX1T1), transcript variant 3

Synonyms:

CDR; ETO; MTG8; AML1T1; ZMYND2; CBFA2T1; AML1-MTG8

SwissProt:

Q06455

WB Predicted band size:

68 kDa

WB Positive control:

Hela, SVT2, A549, COS7, Jurkat, PC12, MCF-7 cell lysates

WB Recommended dilution:

500-2000