小鼠抗METAP2单克隆抗体

Background:

This gene is a member of the methionyl aminopeptidase family and encodes a protein that binds 2 cobalt or manganese ions. This protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent protein. Increased expression of this gene is associated with various forms of cancer and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. A pseudogene of this gene is located on chromosome 2. [provided by RefSeq].

Applications:

WB, IHC, IF, FC

Name of antibody:

METAP2

Immunogen:

Fusion protein of human METAP2

Full name:

methionyl aminopeptidase 2 (METAP2)

Synonyms:

MAP2; MNPEP; p67; p67eIF2

SwissProt:

P50579

IHC positive control:

human pancreas tissue and carcinoma of human thyroid tissue; carcinoma of human prostate tissue and human breast tissue

IHC Recommend dilution:

30-150

WB Predicted band size:

53 kDa

WB Positive control:

HepG2, Hela, A549, COS7, Jurkat, PC-12 cell lysates

WB Recommended dilution:

500-2000