兔抗CMKLR1多克隆抗体

Background:

Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2).

Applications:

ELISA, IHC

Name of antibody:

CMKLR1

Immunogen:

Synthetic peptide of human CMKLR1

Full name:

chemerin chemokine-like receptor 1

Synonyms：

DEZ; RVER1; ChemR23; CHEMERINR

SwissProt:

Q99788

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human thyroid cancer and Human esophagus cancer

IHC Recommend dilution:

25-100