兔抗IRF4多克隆抗体

Background:

The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene.

Applications:

ELISA, IHC

Name of antibody:

IRF4

Immunogen:

Fusion protein of human IRF4

Full name:

interferon regulatory factor 4

Synonyms:

MUM1; LSIRF; SHEP8; NF-EM5

SwissProt:

Q15306

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human brain and human lung cancer

IHC Recommend dilution:

30-150