兔抗ATP6V1H多克隆抗体

Background:

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular organelles. V-ATPase-dependent organelle acidification is necessary for multiple processes including protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. The encoded protein is the regulatory H subunit of the V1 domain of V-ATPase, which is required for catalysis of ATP but not the assembly of V-ATPase. Decreased expression of this gene may play a role in the development of type 2 diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Applications:

IHC

Name of antibody:

ATP6V1H

Immunogen:

Synthesized peptide derived from internal of human ATP6V1H.

Full name:

ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H

Synonyms：

SFD; NBP1; VMA13; CGI-11; MSTP042; SFDbeta; SFDalpha

SwissProt:

Q9UI12

IHC positive control:

Human brain tissue

IHC Recommend dilution:

50-100