兔抗PLOD2多克隆抗体

Background:

The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of this gene are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.

Applications:

ELISA, IHC

Name of antibody:

PLOD2

Immunogen:

Fusion protein of human PLOD2

Full name:

procollagen-lysine,2-oxoglutarate 5-dioxygenase 2

Synonyms:

LH2; TLH; BRKS2

SwissProt:

O00469

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human esophagus cancer

IHC Recommend dilution:

150-300