兔抗IPO4多克隆抗体

Background:

Importin-4 is a protein that in humans is encoded by the IPO4 gene. Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran.

Applications:

ELISA, WB, IHC

Name of antibody:

IPO4

Immunogen:

Fusion protein of human IPO4

Full name:

importin 4

Synonyms：

Imp4

SwissProt:

Q8TEX9

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human colon cancer and human prostate cancer

IHC Recommend dilution:

50-200

WB Predicted band size:

119 kDa

WB Positive control:

Hela cells and human testis tissue, A549, Jurkat and K562 cells

WB Recommended dilution:

500-2000