兔抗IDO2多克隆抗体

Background:

INDOL1 is also known as IDO2 (indoleamine 2,3-dioxygenase 2) and is a 407 amino acid protein that is expressed in various tissues, including liver, small intestine, spleen, placenta, thymus, lung, brain, kidney, colon and dendritic cells. INDOL1 is selectively inhibited by D-1MT (1-methyl-d-tryptophan), which also inhibits IDO (indoleamine 2,3-dioxygenase) and is significant because IDO expression causes suppression of T cell responses to tumors in dendritic cells. The inhibition of INDOL1 by D-1MT suggests a common function in immunomodulation. In the human INDOL1 gene, two single nucleotide polymorphisms have been detected which abolish the enzymatic function of INDOL1.

Applications:

ELISA, WB, IHC

Name of antibody:

IDO2

Immunogen:

Full length fusion protein

Full name:

indoleamine 2,3-dioxygenase 2

Synonyms：

INDOL1

SwissProt:

Q6ZQW0

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human brain

IHC Recommend dilution:

30-150

WB Predicted band size:

45 kDa

WB Positive control:

Human fetal brain tissue and Human kidney tissue

WB Recommended dilution:

500-2000