小鼠抗CDK5(N-term)单克隆抗体

Background:

This gene encodes a proline-directed serine/threonine kinase that is a member of the cyclin-dependent kinase family of proteins. Unlike other members of the family, the protein encoded by this gene does not directly control cell cycle regulation. Instead the protein, which is predominantly expressed at high levels in mammalian postmitotic central nervous system neurons, functions in diverse processes such as synaptic plasticity and neuronal migration through phosphorylation of proteins required for cytoskeletal organization, endocytosis and exocytosis, and apoptosis. In humans, an allelic variant of the gene that results in undetectable levels of the protein has been associated with lethal autosomal recessive lissencephaly-7. Alternative splicing results in multiple transcript variants.

Applications:

WB, IF

Name of antibody:

CDK5(N-term)

Immunogen:

Fusion protein of human CDK5

Full name:

cyclin dependent kinase 5

Synonyms:

LIS7; PSSALRE

SwissProt:

Q00535

WB Predicted band size:

33 kDa

WB Positive control:

3T3, Hela, PC-12, COS7, Jurkat and K562 cell lysates

WB Recommended dilution:

500-2000

IF positive control:

Hela cells

IF Recommend dilution:

50-150