兔抗IKBIP多克隆抗体

Background:

IKIP (Inhibitor of nuclear factor kappa-B kinase-interacting protein, IKK-interacting protein) is a single-pass membrane protein that shares a common promoter with APAF1. APAF1 and IKIP are both induced by X irradiation, however, the two gene products are transcribed in different directions. The IKIP gene is believed to be a target for p53 as expression of IKIP has been shown to promote apoptosis. IKIP has four known isoforms, three of which are found traversing the endoplasmic reticulum membrane. IKIP isoform 4 has a deletion of the transmembrane region which leads to a homogenous distribution of the protein within the cell. The IKIP gene products are expressed in vascular endothelial cells, while the isoform 4 has also been detected in lung, kidney, spleen, thymus and skeletal muscle.

Applications:

ELISA, IHC

Name of antibody:

IKBIP

Immunogen:

Fusion protein of human IKBIP

Full name:

IKBKB interacting protein

Synonyms：

IKIP

SwissProt:

Q70UQ0

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human liver cancer and Human lung cancer

IHC Recommend dilution:

50-200