兔抗ACVR2B多克隆抗体

Background:

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.

Applications:

ELISA, IHC

Name of antibody:

ACVR2B

Immunogen:

Fusion protein of human ACVR2B

Full name:

activin A receptor, type IIB

Synonyms：

HTX4; ACTRIIB; ActR-IIB

SwissProt:

Q13705

ELISA Recommended dilution:

1000-2000

IHC positive control:

Human thyroid cancer and human cervical cancer

IHC Recommend dilution:

25-100