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021-54845833/15800441009
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Background: |
This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul |
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Applications: |
WB |
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Name of antibody: |
PCDHGC5 |
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Immunogen: |
Fusion protein of human PCDHGC5 |
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Full name: |
protocadherin gamma subfamily C, 5 (PCDHGC5), transcript variant 2 |
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Synonyms: |
PCDH-GAMMA-C5 |
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SwissProt: |
Q9Y5F6 |
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WB Predicted band size: |
102 kDa |
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WB Positive control: |
K562, MCF7 and SVT2 cell lysates |
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WB Recommended dilution: |
500-2000 |
