兔抗HLA-E多克隆抗体

Background:

HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail.

Applications:

ELISA, IHC

Name of antibody:

HLA-E

Immunogen:

Fusion protein of human HLA-E

Full name:

major histocompatibility complex, class I, E

Synonyms:

QA1; HLA-6.2

SwissProt:

P13747

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human liver cancer and Human colorectal cancer

IHC Recommend dilution:

50-300