小鼠抗PSMB9单克隆抗体

Background:

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 1 (proteasome beta 6 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. [provided by RefSeq, Mar

Applications:

WB, IHC, IF, FC

Name of antibody:

PSMB9

Immunogen:

Fusion protein of human PSMB9

Full name:

proteasome (prosome, macropain) subunit, beta type, 9 (PSMB9)

Synonyms:

beta1i; LMP2; PSMB6i; RING12

SwissProt:

P28065

IHC positive control:

carcinoma of human liver tissue and carcinoma of human lung tissue; adenocarcinoma of human ovary tissue and adenocarcinoma of human endometrium tissue

IHC Recommend dilution:

30-150

WB Predicted band size:

23 kDa

WB Positive control:

Jurkat cell lysate

WB Recommended dilution:

500-2000