小鼠抗TANK单克隆抗体

Background:

The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Applications:

WB, IHC

Name of antibody:

TANK

Immunogen:

Fusion protein of human TANK

Full name:

TRAF family member associated NFKB activator

Synonyms:

ITRAF; TRAF2; I-TRAF

SwissProt:

Q92844

IHC positive control:

Human colorectal cancer and Human appendix tissue; Human colon tissue

IHC Recommend dilution:

200-500

WB Predicted band size:

48 KD

WB Positive control:

HepG2, Hela, A549, MCF7 cell lysates

WB Recommended dilution:

500-2000