小鼠抗CD44单克隆抗体

Background:

The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq, Jul 2008].

Applications:

WB, IHC, IF, FC

Name of antibody:

CD44

Immunogen:

Fusion protein of human CD44

Full name:

CD44 molecule (Indian blood group) (CD44), transcript variant 1

Synonyms:

CDW44; CSPG8; ECMR-III; HCELL; HUTCH-I; IN; LHR; MC56; MDU2; MDU3; MIC4; Pgp1

SwissProt:

P16070

IHC positive control:

human breast tissue and carcinoma of human lung tissue; human pancreas tissue and carcinoma of human pancreas tissue

IHC Recommend dilution:

30-150

WB Predicted band size:

82 kDa

WB Positive control:

MCF-7 cell lysate

WB Recommended dilution:

500-2000