兔抗CDKL1多克隆抗体

Background:

The activation of signal transduction pathways by growth factors, hormones and neurotransmitters is mediated by the MAP kinases ERK 1 and ERK 2. ERK proteins are regulated by dual phosphorylation at specific tyrosine and threonine sites mapping within a characteristic Thr-Glu-Tyr motif. The protein kinase p56 KKIAMRE is distantly related to the MAP kinase group of proteins and is closely related to p42 KKIALRE. KKIAMRE is predominantly expressed in testis, kidney, brain and lung. KKIAMRE contains the conserved MAP kinase dual phosphorylation motif in the sequence Thr-Asp-Tyr and is activated by treatment of cells by EGF. However, unlike other MAP kinases, the EGF-stimulated kinase activity does not require phosphorylation of KKIAMRE and KKIALRE in the Thr-Asp-Tyr motif.

Applications:

ELISA, WB, IHC

Name of antibody:

CDKL1

Immunogen:

Synthetic peptide of human CDKL1

Full name:

cyclin dependent kinase like 1

Synonyms:

P42; KKIALRE

SwissProt:

Q00532

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human liver cancer and human lung cancer

IHC Recommend dilution:

20-100

WB Predicted band size:

42 kDa

WB Positive control:

Human prostate tissue and Human stomach tissue lysates

WB Recommended dilution:

200-1000