兔抗SCN7A多克隆抗体

Background:

This gene encodes one of the many voltage-gated sodium channel proteins. For proper functioning of neurons and muscles during action potentials, voltage-gated sodium channels direct sodium ion diffusion for membrane depolarization. This sodium channel protein has some atypical characteristics; the similarity between the human and mouse proteins is lower compared to other orthologous sodium channel pairs. Also, the S4 segments, which sense voltage changes, have fewer positive charged residues that in other sodium channels; domain 4 has fewer arginine and lysine residues compared to other sodium channel proteins. Several alternatively spliced transcript variants exist, but the full-length natures of all of them remain unknown.

Applications:

IF

Name of antibody:

SCN7A

Immunogen:

Synthesized peptide derived from internal of human SCN7A.

Full name:

sodium channel, voltage-gated, type VII, alpha subuni

Synonyms：

NaG; SCN6A; Nav2.1; Nav2.2

SwissProt:

Q01118

IF positive control:

A549 cells

IF Recommend dilution:

100-500