小鼠抗ATP2A2单克隆抗体

Background:

This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in multiple transcript variants encoding different isoforms.

Applications:

WB

Name of antibody:

ATP2A2

Immunogen:

Fusion protein of human ATP2A2

Full name:

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

Synonyms:

DD; DAR; ATP2B; SERCA2

SwissProt:

P16615

WB Predicted band size:

115 KD

WB Positive control:

Human muscle tissue lysate

WB Recommended dilution:

200-1000