兔抗ITM2B多克隆抗体

Background:

Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia.

Applications:

ELISA, WB, IHC

Name of antibody:

ITM2B

Immunogen:

Fusion protein of human ITM2B

Full name:

integral membrane protein 2B

Synonyms:

BRI; FBD; ABRI; BRI2; E25B; E3-16; RDGCA; imBRI2; BRICD2B

SwissProt:

Q9Y287

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human liver cancer

IHC Recommend dilution:

30-150

WB Predicted band size:

30 kDa

WB Positive control:

Rat kidney tissue lysate

WB Recommended dilution:

500-2000