小鼠抗ALX4单克隆抗体

Background:

This gene encodes a paired-like homeodomain transcription factor expressed in the mesenchyme of developing bones, limbs, hair, teeth, and mammary tissue. Mutations in this gene cause parietal foramina 2 (PFM2); an autosomal dominant disease characterized by deficient ossification of the parietal bones. Mutations in this gene also cause a form of frontonasal dysplasia with alopecia and hypogonadism; suggesting a role for this gene in craniofacial development, mesenchymal-epithelial communication, and hair follicle development. Deletion of a segment of chromosome 11 containing this gene, del(11)(p11p12), causes Potocki-Shaffer syndrome (PSS); a syndrome characterized by craniofacial anomalies, mental retardation, multiple exostoses, and genital abnormalities in males. In mouse, this gene has been shown to use dual translation initiation sites located 16 codons apart. [provided by RefSeq].

Applications:

WB

Name of antibody:

ALX4

Immunogen:

Fusion protein of human ALX4

Full name:

ALX homeobox 4 (ALX4)

Synonyms:

CRS5; FND2

SwissProt:

Q9H161

WB Predicted band size:

44 kDa

WB Positive control:

Human brain tissue lysate

WB Recommended dilution:

500-2000