兔抗YWHAE多克隆抗体

Background:

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene.

Applications:

ELISA, WB, IHC

Name of antibody:

YWHAE

Immunogen:

Fusion protein of human YWHAE

Full name:

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide

Synonyms：

MDS, MDCR, KCIP-1, 14-3-3E

SwissProt:

P62258

ELISA Recommended dilution:

500-10000

IHC positive control:

Human ovarian cancer and Human thyroid cancer

IHC Recommend dilution:

10-50

WB Predicted band size:

29 kDa

WB Positive control:

Hela, 293T cells, Human fetal brain and Mouse brain tissue

WB Recommended dilution:

500-2000