兔抗JAK1多克隆抗体

Background:

Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs.

Applications:

ELISA, IHC

Name of antibody:

JAK1

Immunogen:

Synthetic peptide of human JAK1

Full name:

Janus kinase 1

Synonyms:

JTK3; JAK1A; JAK1B

SwissProt:

P23458

ELISA Recommended dilution:

500-1000

IHC positive control:

Human tonsil

IHC Recommend dilution:

25-100