兔抗ARHGEF7多克隆抗体

Background:

Rho GTPases play a fundamental role in numerous cellular processes triggered by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It forms a complex with the small GTP binding protein Rac1 and recruits Rac1 to membrane ruffles and to focal adhesions. This protein can induce membrane ruffling. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Applications:

ELISA, WB, IHC

Name of antibody:

ARHGEF7

Immunogen:

Fusion protein of human ARHGEF7

Full name:

Rho guanine nucleotide exchange factor (GEF) 7

Synonyms:

P50; P85; PAK3; PIXB; COOL1; P50BP; COOL-1; P85SPR; BETA-PIX; P85COOL1; Nbla10314

SwissProt:

Q14155

IHC positive control:

Human gastric cancer and human thyroid cancer

IHC Recommend dilution:

50-200

WB Predicted band size:

90 kDa

WB Positive control:

Human brain malignant glioma tissue, A172 and 293T cells

WB Recommended dilution:

500-2000