兔抗ERN2多克隆抗体

Background:

The accumulation of unfolded proteins within the endoplasmic recticulum (ER) of yeast and mammalian cells activates the unfolded protein response (UPR) pathway and leads to the transcription of ER-specific genes involved in protein folding. The activation of the UPR requires the ER transmembrane kinase IRE1p (for inositol-requiring and ER-to-nucleus signaling protein). IRE1α and IRE1β are two mammalian homologs of the yeast IRE1p. These related proteins localize to the ER lumen and contain both a short transmembrane domain that spans the ER membrane and a cytosolic Ser/Thr kinase domain. IRE1 activation involves the oligomerization and trans-phosphorylation of the cytosolic portion of the proteins, which then potentiates its intrinsic kinase activity and, in turn, stimulates transcription of UPR-targeted genes.

Applications:

ELISA, IHC

Name of antibody:

ERN2

Immunogen:

Synthetic peptide of human ERN2

Full name:

endoplasmic reticulum to nucleus signaling 2

Synonyms：

IRE1b; IRE1-BETA

SwissProt:

Q76MJ5

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human liver cancer and Human gastric cancer

IHC Recommend dilution:

50-200