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Background: |
The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. |
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Applications: |
ELISA, WB, IHC |
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Name of antibody: |
TAB3 |
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Immunogen: |
Fusion protein of human TAB3 |
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Full name: |
TGF-beta activated kinase 1/MAP3K7 binding protein 3 |
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Synonyms： |
NAP1; MAP3K7IP3 |
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SwissProt: |
Q8N5C8 |
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ELISA Recommended dilution: |
2000-10000 |
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IHC positive control: |
Human thyroid cancer and human brain |
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IHC Recommend dilution: |
50-200 |
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WB Predicted band size: |
79 kDa |
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WB Positive control: |
293T, Raw264.7, NIH/3T3, K562 and Jurkat cells |
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WB Recommended dilution: |
1000-5000 |
