兔抗ITCH(Phospho-Tyr420) 多克隆抗体

Background:

This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]

Applications:

IHC

Name of antibody:

ITCH(Phospho-Tyr420)

Immunogen:

Peptide sequence around phosphorylation site of tyrosine 420(F-I-Y(p)-G-N) derived from Human ITCH .

Full name:

itchy E3 ubiquitin protein ligase

Synonyms：

AIF4; AIP4; ADMFD; NAPP1; dJ468O1.1

SwissProt:

Q96J02

IHC positive control:

Human brain tissue

IHC Recommend dilution:

50-100