兔抗PGC多克隆抗体

Background:

This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1.

Applications:

ELISA, WB, IHC

Name of antibody:

PGC

Immunogen:

Fusion protein of human PGC

Full name:

progastricsin (pepsinogen C)

Synonyms：

PEPC, PGII

SwissProt:

P20142

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human ovarian cancer and Human colon cancer

IHC Recommend dilution:

25-100

WB Predicted band size:

42 kDa

WB Positive control:

823 cells

WB Recommended dilution:

500-2000