兔抗FBXW8多克隆抗体

Background:

This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.

Applications:

ELISA, IHC

Name of antibody:

FBXW8

Immunogen:

Synthetic peptide of human FBXW8

Full name:

F-box and WD repeat domain containing 8

Synonyms:

FBW6; FBW8; FBX29; FBXW6; FBXO29

SwissProt:

Q8N3Y1

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human esophagus cancer and Human breast cancer

IHC Recommend dilution:

50-300