兔抗FOXO3多克隆抗体

Background:

This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. Interacts with YWHAB/14-3-3-beta and YWHAZ/14-3-3-zeta, which are required for cytosolic sequestration. Upon oxidative stress, interacts with STK4/MST1, which disrupts interaction with YWHAB/14-3-3-beta and leads to nuclear translocation. Interacts with PIM1. Interacts with DDIT3/CHOP.

Applications:

ELISA, IHC

Name of antibody:

FOXO3

Immunogen:

Synthetic peptide of human FOXO3

Full name:

forkhead box O3

Synonyms：

FOXO2, AF6q21, FKHRL1, FOXO3A, FKHRL1P2

SwissProt:

O43524

ELISA Recommended dilution:

1000-5000

IHC positive control:

Human cervical cancer

IHC Recommend dilution:

50-150