兔抗UNC45B多克隆抗体

Background:

This gene encodes a co-chaperone required for folding and accumulation of type II myosins. The protein consists of three tetratricopeptide repeat motifs at the N-terminus that form a complex with heat shock protein 90, a central region of unknown function that is conserved in all Unc-45 proteins, and a C-terminal Unc-45/Cro1/She4 domain. The protein is expressed at high levels in striated muscle, where its muscle myosin chaperone activity is dependent on heat shock protein 90 acting as a co-chaperone. A missense mutation in this gene has been associated with cataract development. Alternative splicing results in multiple transcript variants.

Applications:

ELISA, WB, IHC

Name of antibody:

UNC45B

Immunogen:

Fusion protein of human UNC45B

Full name:

unc-45 myosin chaperone B

Synonyms:

CMYA4; UNC45; CTRCT43; SMUNC45; UNC-45B

SwissProt:

Q8IWX7

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human liver cancer

IHC Recommend dilution:

50-300

WB Predicted band size:

104/95 kDa

WB Positive control:

Human heart tissue lysate

WB Recommended dilution:

500-2000