兔抗NFKB1(Phospho-Ser907)多克隆抗体

Background:

NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity.

Applications:

WB, IHC

Name of antibody:

NFKB1(Phospho-Ser907)

Immunogen:

Peptide sequence around phosphorylation site of serine 907(P-L-S(p)-P-A) derived from Human NFκB-p105/p50.

Full name:

nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

Synonyms:

p50; KBF1; p105; EBP-1; NF-kB1; NFKB-p50; NFkappaB; NF-kappaB; NFKB-p105; NF-kappa-B

SwissProt:

P19838

IHC positive control:

Human breast carcinoma tissue

IHC Recommend dilution:

50-100

WB Predicted band size:

105 kDa

WB Positive control:

Hela cells lysates luntreated or treated with TNF-α

WB Recommended dilution:

500-1000