兔抗MED12多克隆抗体

Background:

The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome.

Applications:

ELISA, IHC

Name of antibody:

MED12

Immunogen:

Synthetic peptide of human MED12

Full name:

mediator complex subunit 12

Synonyms：

OKS; FGS1; HOPA; OPA1; OHDOX; ARC240; CAGH45; MED12S; TNRC11; TRAP230

SwissProt:

Q93074

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human breast cancer

IHC Recommend dilution:

25-100