小鼠抗IL1B单克隆抗体

Background:

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.

Applications:

ELISA, WB

Name of antibody:

IL1B

Immunogen:

Fusion protein of human IL1B

Full name:

interleukin 1 beta

Synonyms:

IL-1; IL1F2; IL1-BETA; IL-1β

SwissProt:

P01584

WB Predicted band size:

31 kDa

WB Positive control:

A549, A172 and HeLa cell, Human fetal liver tissue lysates

WB Recommended dilution:

500-2000