小鼠抗HOXC4单克隆抗体

Background:

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC4, is one of several homeobox HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Two alternatively spliced variants that encode the same protein have been described for HOXC4. Transcript variant one includes the shared exon, and transcript variant two includes only gene-specific exons.

Applications:

WB, IHC

Name of antibody:

HOXC4

Immunogen:

Fusion protein of human HOXC4

Full name:

homeobox C4

Synonyms:

HOX3; cp19; HOX3E

SwissProt:

P09017

IHC positive control:

Human breast tissue and Human lung cancer; Human prostate cancer and Human tonsil tissue

IHC Recommend dilution:

500-2000

WB Predicted band size:

30 KD

WB Positive control:

NIH/3T3, U251, A549 cell lysates

WB Recommended dilution:

500-2000