兔抗NELFA多克隆抗体

Background:

This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation.

Applications:

ELISA, WB, IHC

Name of antibody:

NELFA

Immunogen:

Fusion protein of human NELFA

Full name:

negative elongation factor complex member A

Synonyms:

WHSC2; NELF-A; P/OKcl.15

SwissProt:

Q9H3P2

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human thyroid cancer and human esophagus cancer

IHC Recommend dilution:

25-100

WB Predicted band size:

57 kDa

WB Positive control:

NIH/3T3，RAW264.7 and Hela cell lysates

WB Recommended dilution:

200-1000