兔抗DMBT1多克隆抗体

Background:

Loss of sequences from human chromosome 10q has been associated with the progression of human cancers. The gene DMBT1 was originally isolated based on its deletion in a medulloblastoma cell line. DMBT1 is expressed with transcripts of 6.0, 7.5, and 8.0 kb in fetal lung and with one transcript of 8.0 kb in adult lung, although the 7.5 kb transcript has not been characterized. The DMBT1 protein is a glycoprotein containing multiple scavenger receptor cysteine-rich (SRCR) domains separated by SRCR-interspersed domains (SID). Transcript variant 2 (8.0 kb) has been shown to bind surfactant protein D independently of carbohydrate recognition. This indicates that DMBT1 may not be a classical tumor suppressor gene, but rather play a role in the interaction of tumor cells and the immune system.

Applications:

ELISA, IHC

Name of antibody:

DMBT1

Immunogen:

Synthetic peptide of human DMBT1

Full name:

deleted in malignant brain tumors 1

Synonyms：

GP340; muclin

SwissProt:

Q9UGM3

ELISA Recommended dilution:

1000-2000

IHC positive control:

Human gastric cancer

IHC Recommend dilution:

10-50