兔抗EP300多克隆抗体

Background:

This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer.

Applications:

ELISA, IHC

Name of antibody:

EP300

Immunogen:

Synthetic peptide of human EP300

Full name:

E1A binding protein p300

Synonyms:

p300; KAT3B; RSTS2

SwissProt:

Q09472

IHC positive control:

Human gastric cancer and human thyroid cancer

IHC Recommend dilution:

25-100