兔抗MLH1多克隆抗体

Background:

This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described, but their full-length natures have not been determined.

Applications:

ELISA, IHC

Name of antibody:

MLH1

Immunogen:

Fusion protein of human MLH1

Full name:

mutL homolog 1

Synonyms：

FCC2; COCA2; HNPCC; hMLH1; HNPCC2

SwissProt:

P40692

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human thyroid cancer

IHC Recommend dilution:

50-200