兔抗DR1多克隆抗体

Background:

This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription.

Applications:

ELISA, IHC

Name of antibody:

DR1

Immunogen:

Synthetic peptide of human DR1

Full name:

down-regulator of transcription 1

Synonyms:

NC2; NC2B; NC2-BETA

SwissProt:

Q01658

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human colorectal cancer;

IHC Recommend dilution:

20-100