兔抗CDH1多克隆抗体

WB Recommended dilution:

500-2000

WB Positive control:

Mouse kidney tissue lysate

WB Predicted band size:

97 kDa

IHC Recommend dilution:

25-100

IHC positive control:

Human liver cancer

ELISA Recommended dilution:

5000-10000

SwissProt:

P12830

Synonyms:

UVO; CDHE; ECAD; LCAM; Arc-1; BCDS1; CD324

Full name:

cadherin 1

Immunogen:

Synthetic peptide of human CDH1

Name of antibody:

CDH1

Applications:

ELISA, WB, IHC

Background:

This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16.