兔抗GMNN多克隆抗体

Background:

This gene encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex. The encoded protein is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased expression of this gene may play a role in several malignancies including colon, rectal and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and two pseudogenes of this gene are located on the short arm of chromosome 16.

Applications:

ELISA, WB, IF

Name of antibody:

GMNN

Immunogen:

Synthetic peptide of human GMNN

Full name:

geminin, DNA replication inhibitor

Synonyms：

Gem

SwissProt:

O75496

ELISA Recommended dilution:

200-1000

WB Predicted band size:

24 kDa

WB Positive control:

Hela cells

WB Recommended dilution:

100-500

IF positive control:

NCCIT and F9 cells

IF Recommended dilution:

50-100