兔抗CLDN6多克隆抗体

Background:

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.

Applications:

ELISA, IHC

Name of antibody:

CLDN6

Immunogen:

Synthetic peptide of human CLDN6

Full name:

claudin 6

SwissProt:

P56747

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human colorectal cancer and human esophagus cancer

IHC Recommend dilution:

25-100