小鼠抗EARS2单克隆抗体

Background:

This gene encodes a member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of glutamate to tRNA molecules. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency 12 (COXPD12). Alternative splicing results in multiple transcript variants.

Applications:

WB, IHC

Name of antibody:

EARS2

Immunogen:

Fusion protein of human EARS2

Full name:

glutamyl-tRNA synthetase 2, mitochondrial

Synonyms:

MSE1; gluRS; COXPD12

SwissProt:

Q5JPH6

IHC positive control:

Human breast tissue and Human colon tissue; Human kidney tissue and Human tonsil tissue

IHC Recommend dilution:

200-500

WB Predicted band size:

59 KD

WB Positive control:

H460, A549, HepG2, 293T, U251, Jurkat, MCF7, K562 cell lysates

WB Recommended dilution:

500-2000