兔抗CLCN4多克隆抗体

IF Recommend dilution:

100-500

IF positive control:

Huvec cells

WB Recommended dilution:

500-3000

WB Positive control:

MCF-7 cells lysate

WB Predicted band size:

85 kDa

SwissProt:

P51793

Synonyms：

CLC4; ClC-4; ClC-4A

Full name:

chloride channel, voltage-sensitive 4

Immunogen:

Synthesized peptide derived from internal of human CLCN4.

Name of antibody:

CLCN4

Applications:

WB, IF

Background:

The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 4 has an evolutionary conserved CpG island and is conserved in both mouse and hamster. This gene is mapped in close proximity to APXL (Apical protein Xenopus laevis-like) and OA1 (Ocular albinism type I), which are both located on the human X chromosome at band p22.3. The physiological role of chloride channel 4 remains unknown but may contribute to the pathogenesis of neuronal disorders. Alternate splicing results in two transcript variants that encode different proteins.